Cholinergic Modulation Preserves Spike Timing Under Physiologically Realistic Fluctuating Input

Cholinergic Modulation Preserves Spike Timing Under Physiologically Realistic Fluctuating Input

Effects of cholinergic modulation on responses of neocortical neurons to fluctuating input.

Neocortical neurons in vivo are spontaneously active and intracellular recordings have revealed strongly fluctuating membrane potentials arising from the irregular arrival of excitatory and inhibitory synaptic potentials. In addition to these rapid fluctuations, more slowly varying influences from diffuse activation of neuromodulatory systems alter the excitability of cortical neurons by modula...

Cholinergic modulation of spike timing and spike rate

Little is known about the constraints that neuromodulation places upon neural coding. We investigated the relationship between cholinergic modulation of spike timing and rate in a compartment model of a neocortical neuron. Our results suggest that cholinergic modulation of spike timing is directly related to the modulation of spike rate via the insertion of new spikes, and that spike timing is ...

Channel Stochasticity May Be Critical in Determining the Reliability and Precision of Spike Timing

The firing reliability and precision of an isopotential membrane patch consisting of a realistically large number of ion channels is investigated using a stochastic Hodgkin-Huxley (HH) model. In sharp contrast to the deterministic HH model, the biophysically inspired stochastic model reproduces qualitatively the different reliability and precision characteristics of spike firing in response to ...

Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity.

Correlated presynaptic and postsynaptic activity is the key factor in inducing Hebbian plasticity and memory. However, little is known about the physiological events that could mediate such coordination. Correlated cholinergic input induces spike timing-dependent plasticity-like hippocampal synaptic plasticity. Cholinergic receptors are localized to both presynaptic and postsynaptic glutamaterg...